Pamidronate treatment in resistant cases of CRMO – our small case series
نویسندگان
چکیده
Introduction Chronic recurrent multifocal osteomyelitis (CRMO) is the most common autoinflammatory osteopathy. CRMO is characterized by non-bacterial osteomyelitis and primarily affects children and adolescents. The disorder has a relapsing and remitting course. While non-steroidal anti-inflammatory drugs (NSAIDs) are used as first-line treatment, glucocorticoids and disease-modifying antirheumatic drugs have been reported to be effective in some cases. In resistant cases, the effects of TNF-a inhibitors or bisphosphonates were observed.
منابع مشابه
PReS-FINAL-2229: Pamidronate in CRMO - a small case series
Introduction Chronic recurrent multifocal osteomyelitis (CRMO) is a rare autoinflammatory disorder which affects predominantly girls with peak onset between ages of 7 to 12 years. There is a frequent association of CRMO with inflammatory skin or gut disorders. Patients with isolated CRMO are usually treated with nonsteroidal antiinflammatory drugs (NSAIDs) prior to escalation to corticoids and ...
متن کاملDramatic pain relief and resolution of bone inflammation following pamidronate in 9 pediatric patients with persistent chronic recurrent multifocal osteomyelitis (CRMO)
BACKGROUND Chronic recurrent multifocal osteomyelitis (CRMO) is an inflammatory, non-infectious osteopathy that affects predominantly patients </= 18 years of age. There is no uniformly effective treatment. Our objective is to describe clinical, magnetic resonance imaging (MRI), and bone resorption response to intravenous pamidronate in pediatric CRMO. METHODS We report our prospectively docu...
متن کاملChronic Recurrent Multifocal Osteomyelitis (CRMO): four cases treated with aminobisphosphonate (pamidronate)
CRMO is an autoinflammatory disease of children and young adults, characterized by the insidious onset of local pain and swelling in affected bone and fever. The bone lesions are radiologically characterized as multiple luciens surrounded by defined zones of patchy but dense sclerosis, cortical tickening from periosteal new bone formation, and increased bone size with different bones involved. ...
متن کاملChronic Recurrent Multifocal Osteomyelitis in a 9-year-old Boy
Chronic recurrent multifocal osteomyelitis (CRMO) is a rare aseptic, auto-inflammatory bone disorder. CRMO presents with bone pain with or without fever. The diagnosis of CRMO is a diagnosis of exclusion and should be included in the differential diagnosis of chronic inflammatory bone lesions in children. Cultures of the bone are typically sterile, antibiotic therapy does not result in clinic...
متن کاملNeonatal Hypercalcemia Secondary to Subcutaneous Fat Necrosis Successfully Treated with Pamidronate: A Case Series and Literature Review
Subcutaneous fat necrosis (SCFN) is a noninfectious panniculitis that occurs in term infants who experience significant distress in the 1st weeks of life, including hypoxic ischemic encephalopathy (HIE). Since the introduction of therapeutic hypothermia for HIE, there have been a few published case reports of SCFN, following this modality of treatment. Although, most cases of SCFN resolve spont...
متن کامل